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METHODS AND COMPOSITIONS FOR MODULATING NOTCH ACTIVITY
专利权人:
ARTAVANIS-TSAKONAS; SPYRIDON
发明人:
FLEMING, ROBERT, J.,ARTAVANIS-TSAKONAS, SPYRIDON
申请号:
PH12014502182
公开号:
PH12014502182A1
申请日:
2014.09.29
申请国别(地区):
PH
年份:
2014
代理人:
摘要:
Provided herein are polypeptides and derivatives thereof that contain sequences of a Serrate protein and that inhibit Notch pathway function. Also provided herein are nucleic acids that encode the polypeptides, vectors and cells for producing the polypeptides, and related pharmaceutical compositions and kits. Additionally provided are antibodies which bind to the Notch inhibitory region of a Serrate protein. Therapeutic methods are also provided.
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