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含有脂質胜肽型化合物之增黏性組成物
专利权人:
LTD.;NISSAN CHEMICAL INDUSTRIES
发明人:
IMOTO, TAKAYUKI,井本鹰行,井本鷹行
申请号:
TW104115606
公开号:
TWI662969B
申请日:
2015.05.15
申请国别(地区):
TW
年份:
2019
代理人:
摘要:
There is provided a thickened composition that does not lose viscosity even in the presence of an organic acid such as ascorbic acid or a salt thereof. A thickened composition, comprising a polyhydric alcohol, water, an organic acid, and a lipid peptide-type compound containing at least one of a compound of Formula (1) to Formula (3) below and a pharmaceutically usable salt of the compound of Formula (1) to Formula (3), where R 1 is a C 9-23 aliphatic group, R 2 is a hydrogen atom or a C 1-4 alkyl group that optionally has a C 1-2 branched chain, R 3 is a -(CH 2 ) n -X group, n is a number of 1 to 4, X is an amino group, a guanidino group, a -CONH 2 group, a 5-membered ring group optionally containing 1 to 3 nitrogen atom(s), a 6-membered ring group optionally containing 1 to 3 nitrogen atom(s), or a condensed heterocycle group that contains a 5-membered ring and a 6-membered ring optionally containing 1 to 3 nitrogen atom(s).本發明提供一種即使在抗壞血酸等有機酸或彼等之鹽存在下亦不會喪失黏性之增黏性組成物。本發明之增黏性組成物含有多元醇、水及有機酸、及由以下述式(1)至式(3)表示之化合物或其藥學上可使用之鹽中之至少一種所成之脂質胜肽型化合物。(式中,R1表示碳原子數9至23之脂肪族基,R2表示氫原子、或可具有碳原子數1或2之分支鏈之碳原子數1至4之烷基,R3表示-(CH2)n-X基,n表示1至4之數,X表示胺基、胍基、-CONH2基、或可具有1至3個氮原子之5員環基或6員環基、或由5員環與6員環構成之縮合雜環基)。
来源网站:
中国工程科技知识中心
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