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COMPOSITIONS FOR TREATMENT OF PULMONARY HYPERTENSION, INTRODUCED BY INHALATION, AND WAYS OF THEIR APPLICATION
专利权人:
Л.П. (US);ДЕЙ ФАРМА
发明人:
ЧАУДРИ Имтяз (US)
申请号:
RU2010152753/15
公开号:
RU2010152753A
申请日:
2010.12.23
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A composition administered by inhalation for the treatment of pulmonary hypertension, wherein said composition comprises a therapeutically effective amount of a hypotension reducing agent, wherein said pulmonary hypertension reducing agent is at least one of an ACEI, ARB, beta blocker , a calcium channel blocker or a vasodilator, and said composition is suitable for administration by inhalation to a mammal in need thereof. ! 2. The composition according to claim 1, where the specified composition is acceptable for administration by spray. ! 3. The composition according to claim 2, comprising from about 0.001 mg / ml to about 20 mg / ml of the specified agent that reduces pulmonary hypertension. ! 4. The composition according to claim 2, comprising from about 0.1 mg / ml to about 15 mg / ml of the specified agent that reduces pulmonary hypertension. ! 5. The composition according to claim 2, comprising from about 1 mg / ml to about 10 mg / ml of the specified agent that reduces pulmonary hypertension. ! 6. The composition according to claim 2, where the specified composition is a solution. ! 7. The composition according to claim 6, where the specified solution is sterile. ! 8. The composition according to claim 7, where the specified solution is isotonic. !9. The composition of claim 8, wherein said solution has a pH from about 3 to about 8.! 10. The composition according to claim 9, where the specified solution includes a buffer. ! 11. The composition of claim 10, where the specified buffer is one selected from the group consisting of sodium hydroxide, sodium citrate and citric acid. ! 12. The composition of claim 2, wherein said composition is an aqueous suspension. ! 13. The composition according to p. 12, where indicated1. Композиция, вводимая путем ингаляции, для лечения легочной гипертензии, где указанная композиция включает терапевтически эффективное количество агента, снижающего гипертензию, при этом указанный агент, снижающий легочную гипертензию, предста
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