Medina-Selby, Angelica,McCoin, Colin,Vajdy, Michael,Coit, Doris,Houghton, Michael
申请号：
AU2006335256
公开号：
AU2006335256B2
申请日:
2006.11.22
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Immunogenic compositions that elicit immune responses against Norovirus andSapovirus antigens are described. In particular, the invention relates to polynucleotidesencoding one or more capsid proteins or other immunogenic viral polypeptidesfrom one or more strains of Norovirus and/or Sapovirus, coexpression of suchimmunogenic viral polypeptides with adjuvants, and methods of using the polynucleotidesin applications including immunization and production of immunogenic viralpolypeptides and viral-like particles (VLPs). Methods for producing Norovirus-or Sapovirus-derived multiple epitope fusion antigens or polyproteins andimmunogenic compositions comprising one or more immunogenic polypeptides,polynucleotides, VLPs, and/or adjuvants are also described. The immunogeniccompositions of the invention may also contain antigens other than Norovirusor Sapovirus antigens, including antigens that can be used in immunization againstpathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
