New pyrazolopyridine derivatives are p38 kinase inhibitors useful in medicaments for the treatment or prevention of e.g. cardiovascular diseases, neurodegenerative diseases and proliferative diseases
Pyrazolopyridine derivatives (I), their salts, solvates and prodrugs are new. Pyrazolopyridine derivatives of formula (I), their salts, solvates and prodrugs are new. [Image] A : N or N +>；O ->；； R 1>；phenyl or het (optionally substituted with one or more substituents of R-a or R-b)； R 2>；het (optionally substituted with one or more substituents of R-a or R-b)； either R 3>；H, Cy (optionally substituted with one or more substituents of R-a or R-b)； or R 3>；1-6C alkyl (optionally substituted with one or more substituents of R-b or Cy*) Cy* : optionally substituted with one or more substituents of R-b or R-c； R 4>；H, R-a, halo, OR-a', OCOR-a, OSO 2R-a, OCONR-aR-a', NO 2, CN, COR-a', CO 2R-a', CONR-a'R-a', NR-a'R-a', NR-a'COR-a', NR-a'CONR-a'R-a', NR-a'CO 2R-a, NR-a'SO 2R-a, SR-a', SOR-a, SO 2Ra or SO 2NR-a'R-a'； R 5>； = H or R-f (where R 5>； can be placed on any of the 2 N of the pyrazole ring)； R-a : 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl or Cy (where the groups 1-6C alkyl, 2-6C alkenyl or 2-6C alkynyl optionally substituted with one or more substituents of R-b or Cy*, and where any of the groups Cy or Cy* optionally substituted with one or more substituents of R-b or R-c)； R-a' : H or R-a； R-b : halo, OR-c', OCOR-c, OSO 2R-c, OCONR-cR-c', NO 2, CN, COR-c', CO 2R-c', CONR-c'R-c', CONR-c'NR-c'R-c', NR-c'R-c', NR-c'COR-c', NR-c'CONR-c'R-c', NR-c'CO 2R-c, NR-c'SO 2R-c, SR-c, SOR-c, SO 2R-c, SO 2NR-c'R-c', C(NR-c')NR-c'R-c', C(NSO 2NR-c'R-c')NR-c'R-c', C(NOR-c')R-c', C(NNR-c'R-c')R-c', NR-c'C(NR-c')NR-c'R-c' or NR-c'C(NCN)NR-c'R-c'； R-c : 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl or Cy (where all these groups optionally substituted with one or more substituents R-d)； R-c' : H or R-c； R-d : halo, R-e, OR-e', OCOR-e, OSO 2R-e, OCONR-eR-e', NO 2, CN, COR-e', CO 2R-e', CONR-e'R-e', CONR-e'NR-e'R-e', NR-e'R-e', NR-e'COR-e', NR-e'CONR-e'R-e', NR-e'CO 2R-e, NR-eSO 2R-e, SR-e', SOR-e, SO 2R-e, SO 2NR-e'R-e', C(NR-e')NR-e'R-e', C(NSO 2NR-e'R-e')NR-e'R-e', C(NOR-e')R
