PONS JAUME,DEMING LAURA,GOODMAN COREY,SIM BANG JANET,KAUDER STEVEN ELLIOT,WAN HONG,KUO TRACY CHIA-CHIEN
申请号:
CL2020000531
公开号:
CL2020000531A1
申请日:
2020.03.04
申请国别(地区):
CL
年份:
2020
代理人:
摘要:
T. lt; P gt; this note; oacute; n introduces architecture and polyacrylonitrile amphetamine; eacute; pat amp extract; Iacute; se amp regulator; ntilde; ales (sirp-a), which are amp; uacute; tiles, for example,(b) In any case, States parties shall: One C amp; eacute; Lula cancerosa or one C amp; eacute; Lula de la sistema immune system,Increase the blood sugar of C amp; eacute; Lula Diana, eliminate C amp; eacute; immune cells, such as lymphocyte regulation, eliminate C amp; eacute; cancer cells, and treat diseases (e.g., research and development)C amp; Aacute; NCER; or any combination of CI amp; s; oacute; of a subject. The architecture of sirp-a includes a high affinity sirp-a D1 domain or its variants, which combines CD47 with M amp; Aacute; s is higher than that of wild sirp-a. The impregnation of architectural or polypropylene acrylonitrile-amp; eacute; sirp-a includes a variant of sirp-a of type D1, which is combined with Mon amp; oacute; ALB amp; uacute; Mina amp; eacute; Rica (HSA) in FC field only,One P amp; eacute; pfido uni amp; oacute; Na ALB amp; uacute; Mina or un pol amp; Iacute; pure polyethylene (PEG). The components provided in this document include (I) a polypropylene and acrylonitrile; eacute; a D1 variant including protein and acrylonitrile; Iacute; a regulator of Se amp; ntilde; ales a (sirp-a) and (b) an antibody / P gt; and;<;p>;LA PRESENTE DESCRIPCIÓ;N PRESENTA CONSTRUCCIONES Y POLIPÉ;PTIDOS DE LA PROTEÍ;NA REGULADORA DE SEÑ;ALES (SIRP-A) QUE SON Ú;TILES, P. EJ., PARA DIRIGIRSE A UNA CÉ;LULA (P. EJ . UNA CÉ;LULA CANCEROSA O UNA CÉ;LULA DEL SISTEMA INMUNITARIO), AUMENTAR LA FAGOCITOSIS DE LA CÉ;LULA DIANA, ELIMINAR CÉ;LULAS INMUNITARIAS TALES COMO LINFOCITOS T REGULADORES, DESTRUIR CÉ;LULAS CANCEROSAS, TRATAR UNA ENFERMEDAD (P. EJ., UN CÁ;NCER) EN UN SUJETO, O CUALQUIER COMBINACIÓ;N DE ESTAS OPCIONES. LAS CONSTRUCCIONES DE SIRP-A INCLUYEN