It treats or inhibits the invention discloses compound and using such compound including mitochondrial disease, energy processing obstacle is impaired, neurodegenerative disease and diseases of aging oxidative stress obstacle or adjust one or more energy biological markers make one or more energy biological marker normalizations or the method for the one or more energy biological markers of enhancing, wherein the compound is tocopherol quinone derivative. The present invention further discloses the compounds, composition and method for treating or preventing radioactive exposure.