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CNS-TARGETED CONJUGATES HAVING MODIFIED FC REGIONS AND METHODS OF USE THEREOF
专利权人:
发明人:
申请号:
EP14766074.0
公开号:
EP3038657A2
申请日:
2014.08.28
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
Provided are central nervous system (CNS)-targeted antibody or therapeutic Fc-fusion polypeptide conjugates having modified Fc regions, and related methods of use thereof, for instance, to facilitate delivery of therapeutic and/or diagnostic polypeptides across the blood-brain barrier (BBB), and thereby treat and/or diagnose conditions associated with the CNS, including cancer, pain, and various neuropathologies, such as neuroinflammatory, auto-immune, and/or neurodegenerative disorders.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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