MCLEAN, KIRK,HERMISTON, TERRY,BROOKS, ALAN,FELDMAN, RICHARD
申请号：
CA2962896
公开号：
CA2962896A1
申请日:
2015.09.29
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Compositions and methods are provided for therapeutic treatment using recombinant Hemopexin molecules having sufficient sialyation and/or absence of neutral glycans to allow for sufficient circulation to remove free heme from a biological organism. In other embodiments, a recombinant Hemopexin molecule is provided for therapeutic treatment having a percentage of neutral glycans to total glycans in a range of from about 2 to about 30 percent as measured by HPLC after labelling with fluorescent probe 2-aminobenzoic acid. Methods of treatment and making a recombinant Hemopexin molecule are also described.
