An endoscopic surgical cutting stapler with a replaceable staple cartridge (9) includes a stapler body (5), an end effector (2), an extension tube(4) connecting the stapler body (5) and the end effector (2), and an operating mechanism (6) controlling the action of the end effector (2). The end effector (2) consists of an effector frame (7), a slide bar (8), a staple cartridge (9), and an anvil (10). The staple cartridge (9) consists of a staple cartridge housing (11), staple pushers (12), a staple pushing sled (13) and staples (14). Staple slots (15), staple pushing apertures (16), a sled slot (17), and a knife pushing slot (18) are provided in the staple cartridge housing (11). A cutting knife (21) is installed in the knife pushing slot (18) of the staple cartridge housing (11). An arcuate slide slot (23) is provided on a proximal end of the staple cartridge housing (11), and an arcuate bump (25) is provided on the cutting knife (21). Before use of the staple cartridge (9), the arcuate bump (25) of the cutting knife (21) is inserted in the arcuate slide slot (23) of the staple cartridge housing (11) to position the knife blade (29) of the cutting knife (21) in the knife pushing slot (18) of the staple cartridge housing (11). In use of the staple cartridge (9), the slide bar (8) is moved from the proximal end to the distal end of the staple cartridge (9). Firstly the slide bar (8) pushes the cutting knife (21) and pushes the arcuate bump (25) of the cutting knife (21) out of the arcuate slide slot (23) of the staple cartridge housing (11) so that the knife blade (29) of the cutting knife (21) protrudes out of the knife pushing slot (18) of the staple cartridge housing (11), and then the slide bar (8) pushes the cutting knife (21) to move in the knife pushing slot (18) of the staple cartridge housing (ll).When the staple pushing sled (13) pushes the staple pushers (12) with its sloped surface to move in the staple pushing apertures (16), the staples (14) are pushed o
