Preferably, an embodiment of a vein presentation enhancement device includes at least, an interior cover supporting a first fastening member, and an exterior cover communicating with the interior cover, wherein the exterior cover provides a first securement member that interacts with the first fastening member to secure the preferred device positioned about a limb of a subject. The preferred embodiment further includes a bladder formed between the interior and exterior covers, and an air transfer assembly connected to said bladder for transfer of air into and out of said bladder, wherein said interior and exterior covers collectively provide a plurality of projections defining a blood access window.
