Bioszintetikus rendszer, amely immunogén poliszaccharidokat termel prokarióta sejtekben

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专利权人:

GlaxoSmithKline Biologicals S.A.

发明人:

WACKER, Michael,WAECHTER, Charles

申请号：

HUE10831896

公开号：

HUE038456T2

申请日:

2010.11.16

申请国别(地区):

HU

年份:

2018

代理人:

摘要：

The invention is directed to bioconjugate vaccines comprising N-glycosylated proteins. Further, the present invention is directed to a recombinant prokaryotic biosynthetic system comprising nucleic acids encoding an epimerase that synthesizes an oligo- or polysaccharide having N-acetylgalactosamine at the reducing terminus. The invention is further directed to N-glycosylated proteins containing an oligo- or polysaccharide having N-acetylgalactosamine at the reducing terminus and an expression system and methods for producing such N-glycosylated proteins.

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