A medicament delivery device is disclosed, comprising a cannula for delivery of the medicament, a cartridge assembly comprising a cartridge having a medicament chamber and a collar adjacent a distal end opening of the chamber, a sealing element for sealing the distal end opening, and a coupling element for retaining the sealing element against a distal end of the cartridge. The device further comprises a hub assembly comprising a hub body and a sealing element release member. The device is switchable from a starting configuration in which the release member is spaced from the sealing element to an activated configuration in which the release member cooperates with the sealing element to connect the medicament chamber to the cannula. The coupling element comprises an annular clamping portion for applying a clamping force to the sealing element to seal the sealing element against the distal end of the cartridge, and a generally tubular engagement portion that extends distally from the clamping portion, the engagement portion being cooperable with the hub body to define a release member chamber. An aseptic seal is disposed between the engagement portion and the hub body to seal at least a proximal end of the release member in the release member chamber when the device is in the starting configuration. The coupling element is attached to the cartridge by a crimp fitting.L'invention concerne un dispositif d'administration de médicament, comprenant une canule pour l'administration du médicament, un ensemble cartouche comprenant une cartouche ayant une chambre de médicament et un collier adjacent à une ouverture d'extrémité distale de la chambre, un élément d'étanchéité pour sceller l'ouverture d'extrémité distale, et un élément de couplage pour retenir l'élément d'étanchéité contre une extrémité distale de la cartouche. Le dispositif comprend en outre un ensemble moyeu comprenant un corps de moyeu et un élément de libération d'élément d'étanchéité. Le dispositif peut pass
