A solid drug solution perforator (40Q) containing drug particles (402) and/ordrug adsorbed or loaded particles with an associated drug reservoir (SSPP system)are provided for delivering therapeutic, prophylactic and/or cosmetic compounds,diagnostics, and for nutrient delivery and drug targeting For drug delivery,the SSPP system includes an active drug ingredient in particulate form (402)or drug adsorbed on the particle surface in a matrix material (41 1) that dissolvesupon contact with a patients body (1 1). In a preferred method of transdermaldrug delivery, an SSPP system containing a drug-adsorbed microparticle (402)penetrates into the epidermis (15) or dermis (17), and the drug (402) is releasedfrom the (dissolving) SSPP system perforator (400) and desorbed from the particles.An additional drug is optionally delivered from a patch reservoir (601) throughskin pores created by insertion of the perforator (602). Formulation and fabricationprocedures for the SSPP and associated reservoir are also provided. An SSPP systemcan be fabricated with a variety of shapes and dimensions.
