Procedure for preparing enteric-coated pellets containing a proton pump inhibitor with benzimidazole structure, useful for preparing multi-particle pharmaceutical compositions for oral use that comprises the following stages: I) coat pure cellulose cores with a hydroalcoholic suspension that contains the proton pump inhibitor, a dibasic amino acid and polyvinylpyrrolidone； II) isolate the coated pure cellulose cores obtained in Stage I； III) apply an enteric coating to the particles obtained in Stage II above； and IV) dry the particles obtained in Stage III above and separate by size.
