CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);UNIVERSITE PARIS DESCARTES;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS
发明人:
Guy CHABOT,Sylviane GIORGI-RENAULT,Stéphanie DESBENE-FINCK,Philippe HELISSEY,Raphaël LABRUERE,Marléne TESTUD,Daniel SCHERMAN
申请号：
US15111711
公开号：
US20160333022A1
申请日:
2015.01.15
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to 4-azapodophyllotoxin analogs of formula (I) in which X, R1, R2, R3, R4 and Ar are as defined in claim 1, preferably a pharmaceutically acceptable salt thereof, optionally in the form of a solvate, a composition comprising said analogs, their use as medicament, in particular for the treatment of cancer, and a process for their preparation.
