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Aqueous Pharmaceutical Composition With Enhanced Stability
专利权人:
NOVARTIS AG
发明人:
David L. Meadows,Howard Allen Ketelson,Jang-Shing Chiou,James W. Davis
申请号:
US14468243
公开号:
US20140364422A1
申请日:
2014.08.25
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present invention is an aqueous pharmaceutical composition that includes an ionized therapeutic agent, an ionic component and guar gum. The guar gum is present in the composition a concentration sufficient to limit interactions between the ionized therapeutic agent and the ionic component thereby imparting stability to the composition. The composition is preferably at or near physiologic pH. The aqueous pharmaceutical composition has been found particularly useful as an aqueous ophthalmic, otic or nasal composition. The pharmaceutical composition, due to its characteristics, is particularly suitable as an ophthalmic composition.
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