FORMULATIONS COMPRENANT UN SEL DE MEGLUMINE DU COMPLEXE METALLIQUE GD-DOTA

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专利权人:

GE HEALTHCARE AS

发明人:

MEIJER, ANDREAS RICHARD,THANING, MIKKEL JACOB

申请号：

CA2967876

公开号：

CA2967876A1

申请日:

2015.11.27

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

The present invention relates to a method of preparation of formulations of gadolinium metal complexes of the macrocyclic chelator DOTA as a meglumine salt, which further comprise a small excess of free DOTA. The method uses controlled conditions such that excess gadolinium is present as a precipitate of gadolinium oxide, with filtration to remove the excess, prior to the addition of a defined excess of DOTA chelator. Also provided is a method of preparation ofMRI contrast agents based on Gd-DOTA.

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