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Clathrin-binding peptide derivative
专利权人:
国立大学法人信州大学
发明人:
宮川 眞一,清水 明,北原 弘恵,増本 純也
申请号:
JP2009250552
公开号:
JP5493714B2
申请日:
2009.10.30
申请国别(地区):
JP
年份:
2014
代理人:
摘要:
<;P>;PROBLEM TO BE SOLVED: To provide a clathrin-bonding peptide derivative that indwells solely in a cell, competitively inhibits bonding of GRP78 to a clathrin thereby exhibiting an excellent anticancer action when administered together with an anticancer agent, is safe, causes little side effects even when applied in combination with an anticancer agent, has a low molecular weight and can be mass-productively manufactured inexpensively in a good yield, and a drug-transporting material comprising the same. <;P>;SOLUTION: The clathrin-bonding peptide derivative contains an amino acid sequence of Thr-Pro-Val-Leu-Glu-Thr-Pro-Lys-Leu-Leu-Leu-Trp. The drug-transporting material includes a colloid particle that contains the clathrin-bonding peptide derivative or a peptide-incorporated phage where the clathrin-bonding peptide derivative is chemically bonded extendedly to the end of a coat protein of the phage, and has the clathrin-bonding peptide derivative exposed on the surface thereof. <;P>;COPYRIGHT: (C)2011,JPO&INPIT
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