Problem to be solved: to provide therapeutic agents for aggressive fibroblasts, which are the cause cells of periodontitis.As a result of analyzing miRNA of aggressive fibroblast, the expression of hsa-mir-21-5p, hsa-mir-497-5p, hsa-mir-885-3p, hsa-mir-374 b-5p, hsa-mir-355-5p changes It became clear. A therapeutic agent for periodontitis with polynucleotides that regulate the expression of these miRNAs.A periodontitis agent that is an miRNA mimic that mimics the expression of hsa-mir-365a-5p, an inhibitor of said miRNA.Diagram【課題】歯周炎の原因細胞であるアグレッシブ線維芽細胞の治療薬の提供。【解決手段】アグレッシブ線維芽細胞のmiRNAを解析した結果、hsa-miR-21-5p、hsa-miR-497-5p、hsa-miR-885-3p、hsa-miR-374b-5p、hsa-miR-365a-5pの発現が変化していることが明らかとなった。これらmiRNAの発現を調節するポリヌクレオチドを有効成分とする歯周炎の治療剤。前記miRNAの阻外剤でありhsa-miR-365a-5pの発現をミミックするmiRNAミミックである歯周炎治療剤。【選択図】図1
