Hepatitis-B viral variants with reduced susceptibility to nucleoside analogs and uses thereof

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专利权人:

INNOGENETICS N.V.

发明人:

BOZDAYI MITHAT

申请号：

US20060375585

公开号：

US7422848(B2)

申请日:

2006.03.15

申请国别(地区):

美国

年份:

2008

代理人:

摘要：

The present invention relates generally to the field of Hepatitis B variants exhibiting a reduced sensitivity to nucleoside analogues, both in vivo and in vitro. More in particular, reverse transcriptase mutant rtA181S is provided. Present invention provides assays and methods for detecting such variant, which assays are useful in monitoring anti-viral therapeutic regimes and adjusting patient therapy. A diagnostic kit for detecting the presence of an HBV variant in a biological sample has also been described.

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