ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
发明人:
Victor J. Hruby,Minying Cai
申请号：
US16431361
公开号：
US20190309022A1
申请日:
2019.06.04
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Modulators of melanocortin receptors (MCR) are provided herein. An MC5R peptide ligand is represented by to Formula 1:R1-Nle4-c[Xaa5-Yaa6-(NMe)D-Nal(2′；)7-Arg8-Trp9-(NMe)Zaa10]-R2.R1 can be an acetyl, a glycosylated amino acid, —；CO—；(CH2)nCH3, or —；CO—；(CH2)nCF3 with n ranging from 1 to 6. R2 can be an —；CONH2, —；COON, or —；CH2OH. Xaa, Yaa, and Zaa can each be a natural amino acid or an unnatural amino acid.
