SHEKHAR, SHASHANK,FRANCZYK, THADDEUS S.,BARNES, DAVID M.,DUNN, TRAVIS B.,HAIGHT, ANTHONY R.,CHAN, VINCENT S.
申请号：
PE2013000078
公开号：
PE20131086A1
申请日:
2011.07.15
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
A process for the production of N - (6 - (3-tert-butil-5 - (2,4-dioxo-3,4-dihydropirimidin-1 (2H) - IL) - 2-methyl) naftelen-2-il) metasulfonamide (complex a) or salt, including sulfamide using a metal transition catalyst precursor (5), such as the precursor and ligation of a spade catalyst. As phosphates, in the case of substrates and solvents such as cesium carbonate and sodium carbonate, such as tetrahydrofuran and n-methyl-pyridine, R1a is phenyl, Perfluorobutyl and phosphate, its content is 7, 7, 9, 9-tetramethyl-8 - (2 ', 4', 6 '- Diisopropyl biphenyl-2-il) - 1, 4-dioxo-8-phosphate-4, 5,2,2,6,6-tetrametry. 1. (2 ', 4', 6 '- trisopropilbiphenil-2-il) phosphonine, etc. The compound (5) is prepared for the reaction of 1 - (3-tert-butil-5 - (6-hydroxinatalen-2-il) - 4-methoxifenil) pirimidin-2, 4 (1H, 3H) - Diona (compound 4) with perfluorobutyryl fluoride in the presence of alkali and solvent. 1 - (3-tert-butil-5-iodo-4-methoxifenil) pirimidin-2, 4 (1H, 3H) - Diona is butted with 6-hydroxynatalen-2-ilboronico. In the case of phosphoric acid esters such as Tributylphosphate and 2-furl-phosphate, among others, there is a precursor of metal transition catalyst, such as diene (II),4.Tetrakis（Trifenilfasin）Paladio（0），It includes, among other things, cesium carbonate, cesium fluoride, etc. These compounds are inhibitors of hexachlorobenzeneREFERIDA A UN PROCEDIMIENTO PARA PREPARAR N-(6-(3-TERT-BUTIL-5-(2,4-DIOXO-3,4-DIHIDROPIRIMIDIN-1(2H)-IL)-2-METOXIFENIL)NAFTALEN-2-IL)METANSULFONAMIDA (COMPUESTO A) O UNA SAL DEL MISMO, QUE COMPRENDE SULFONAMIDAR EL COMPUESTO (5) MEDIANTE UN PRECURSOR DE CATALIZADOR DE METAL DE TRANSICION TAL COMO UN PRECURSOR DE CATALIZADOR DE PALADIO Y UN LIGANDO TAL COMO UNA FOSFINA, EN PRESENCIA DE UNA BASE TAL COMO CARBONATO DE CESIO, CARBONATO DE SODIO, ENTRE OTROS Y UN SOLVENTE TAL COMO TETRAHIDROFURANO, N-METIL-PIRROLIDONA, ENTRE OTROS, DONDE R1a ES FENILO, PERFLUOROBUTILO, ENTRE OTROS Y LA FOSFINA ES 7,7,9,9-TETRAMETIL-8-(2',4',6'-TRIISOPROPI
