nucleic acid-based construct, vector, self-amplifying rna and dna molecules, composition, method for inducing an immune response against a disease caused by a lyssavirus, process for producing a rna-based vaccine, and, using the vector construct, of the self-amplifying RNA molecule or composition.
ALAN STOKES,DONG YU,KATHRYN HASHEY,MARCELO SAMSA,OLGA SLACK,PADMA MALYALA,RASHMI JALAH
申请号：
BR112020000802
公开号：
BR112020000802A2
申请日:
2018.07.16
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
Nucleic acid-based vaccine constructs that encode lyssaviral antigens are useful in preventing and treating disease. self-amplifying RNA molecules encoding lyssaviral antigens provide potent and long-lasting immunity.construtos de vacina baseados em ácido nucleico que codificam antígenos lyssavirais são úteis na prevenção e no tratamento de doenças. moléculas de rna autoamplificáveis que codificam antígenos lyssavirais proveem imunidade potente e de longa duração.
