The present invention relates generally to medical devices for sealing and closing passages formed through tissue. More specifically, the present invention relates to devices for sealing or closing an opening formed through biological tissue comprising a distal or outside margin or surface, and a proximal or inside margin or surface (i.e., a wall thickness). The openings comprise percutaneously formed punctures, incisions, or other openings formed through biological tissue, such as in blood vessels, organs, and the like.
