The present invention relates to methods and compositions for modulating angiogenesis. In particular, the present invention relates to Pigment Epithelial-derived Factor (PEDF) fragments for use in modulating angiogenesis and treating angiogenesis mediated disease. In some embodiments, the present invention provides compositions comprising an isolated peptide, wherein the peptide consists of an amino acid sequence selected from: SEQ ID NOs:2, 12, 13, 22, 23, 33, 34, 41, 42, 43-49, 52, 53, 62, 63, 73, 74, 84, 85, and 92-118. In other embodiments, the peptide comprises, or consists of, SEQ ID NOs: 1-49 and 52-118. In certain embodiments, the peptide comprises, or consists of, or consists essentially of SEQ ID NO:102 (NFGYDLYRVRS). In certain embodiments, one or more of the amino acid in any of these sequences are substituted with modified versions of the appropriate amino acid or amino acids that do not detrimentally affect the anti-angiogenic activity of the peptide.La présente invention concerne des procédés et des compositions qui permettent de moduler langiogenèse. En particulier, la présente invention concerne des fragments de facteur de dérivé épithélial pigmentaire (PEDF) pour lutilisation dans la modulation de langiogenèse et le traitement dune maladie à médiation par langiogenèse.
