Takeda Pharmaceutical Company Limited;Japan Poliomyelitis Research Institute
发明人:
Shimizu, Bunshichi,Abe, Shinobu
申请号：
AU2007305595
公开号：
AU2007305595B2
申请日:
2007.09.28
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Disclosed is a method for the preparation of a mixed vaccine comprising an inactivated poliovirus Sabin strain, a protective antigen against , a diphtheria toxoid and a tetanus toxoid, which involves the step of producing a poliovirus Sabin strain having a high titer. Specifically disclosed is a method for the preparation of a mixed vaccine, which comprises the step of culturing a Vero cell to be inoculated with a poliovirus Sabin strain, in the presence of about 4 to 6 g/L of a microcarrier. The method is useful for producing a mixed vaccine containing an inactivated poliovirus Sabin strain efficiently.
