The present invention is directed to indole derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.本發明係關於吲哚衍生物、含有彼等之醫藥組成物及其在治療及/或預防藉由拮抗一或多種升糖素受體而改善的病症及病況(包括例如代謝疾病,諸如第II型糖尿病及肥胖)上的用途。