Provided are alcohol-free antimicrobial compositions comprising benzalkonium chloride, antimicrobial phospholipid, water, and optionally, polyol co-solvent and/or surfactant. Also provided are alcohol-free antimicrobial compositions comprising quaternary ammonium salt, polyol co-solvent and/or surfactant, and water. Preferably, the compositions are formulated for use as a skin sanitizer.