A fastener cartridge is disclosed which comprises a cartridge body, a deck, a plurality of fastener cavities, and a plurality of fasteners removably stored within the fastener cavities. The fastener cartridge further comprises a tissue thickness compensator positioned over the fastener cavities configured to be captured within the fasteners, wherein the tissue thickness compensator is configured to adapt to the thickness of the tissue captured within the fasteners. The tissue thickness compensator comprises a first compression zone having a first set of material properties and a second compression zone having a second set of material properties, wherein a property in the first set of material properties is different than a corresponding property in the second set of material properties.