A hemodiafiltration system in accordance with an embodiment of the described system at least two dialyzers for hemodiafiltration, at least one dialysate supply, a sterility filter for generating a sterile substitution fluid, and a control unit which controls fluid (e.g., dialysate, substitution fluid, and blood) inputs and outputs to and from each of the at least two dialyzers, the at least one sterility filter, and the dialysis machine. The hemodiafiltration system described herein is capable of executing blood processing with enhanced clearance of small, middle, and large molecules using features that include independently supplying dialysate to multiple dialyzers.
