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Tetrahydrocarboline derivative
专利权人:
Ltd.;ONO PHARMACEUTICAL CO;ONO Pharmaceutical Co.
发明人:
OHATA, Akira,NAKATANI, Shingo,SUGIYAMA, Tetsuya,MORIMOTO, Takashi,OHATA AKIRA,OHATA, AKIRA,NAKATANI SHINGO,NAKATANI, SHINGO,SUGIYAMA TETSUYA,SUGIYAMA, TETSUYA,MORIMOTO TAKASHI,MORIMOTO, TAKASHI
申请号:
ES12761051
公开号:
ES2587856T3
申请日:
2012.01.05
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound represented by the general formula (I): ** Formula ** in which ** Formula ** represents: ** Formula ** in which R1 represents a C2-4 alkyl group, a dihalomethyl group, a trihalomethyl group , a dihalomethoxy group, a trihalomethoxy group, or ** Formula ** in which E represents an oxygen bond or atom; R1-1 represents a dihalomethyl group, a trihalomethyl group, a dihalomethoxy group or a trihalomethoxy group; m represents an integer of zero or one; R2 represents a hydrogen atom, a halogen atom or a methyl group; the bond represented by an arrow is attached to the methylene group represented by "a" in the general formula (I), with the proviso that when ring A is benzene, each of R1 and R2 attached to adjacent carbon atoms can form thiophene, together with the benzene that has the adjacent carbon atoms to which they are attached, or when ring A is thiophene, each of R1 and R2 attached to adjacent carbon atoms can form a benzene, together with the carbon atoms adjacent to those that are attached; R3 represents a hydrogen atom or a C1-4 alkyl group, each of R4a and R9b independently represents a hydrogen atom or a methyl group, Ring U1 represents benzene, cyclohexene, pyridine, cyclobutane, cyclopentane, bicyclo [2, 2 , 2] octane, bicyclo [2, 2, 1] heptane, adamantine, piperidine, piperazine, diazabicyclo [2, 1] heptane or a tetrahydro pyridine group, R5 represents a halogen atom, a methyl group, a methoxy group or an ethoxy group, R6 represents a halogen atom or a methyl group, k represents an integer from zero to three, n represents an integer from zero to three, with the proviso that a plurality of groups represented by R5 and R8 they may be the same or different, respectively, a salt thereof or a solvate thereof.Un compuesto representado por la formula general (I):**Fórmula** en la que**Fórmula** representa:**Fórmula** en las que R1 representa un grupo alquilo C2-4, un grupo dihalometilo, un grupo trihalometilo, un grupo dihalometoxi, un grupo trihalometox
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