MUTATED TRUNCATED VON WILLEBRAND FACTOR

• 收藏
• 分享

专利权人:

CSL BEHRING RECOMBINANT FACILITY AG

发明人:

ANDREWS, Arna,PANOUSIS, Con,EMMRICH, Kerstin,WILSON, Michael,DOWER, Steve,HARDY, Matthew,HARTMAN, Dallas

申请号：

SG11201805497Q

公开号：

SG11201805497QA

申请日:

2017.01.06

申请国别(地区):

SG

年份:

2018

代理人:

摘要：

The present invention provides a modified polypeptide which binds Factor VIII. The polypeptide comprises truncated von Willebrand Factor (VWF) which comprises a sequence as shown in SEQ ID NO:3 or a fragment thereof or a sequence 90% identical thereto, wherein the truncated VWF comprises at least one modification in comparison to SEQ ID NO: 3 in at least one position selected from the group consisting of SI, S3, LI 8, V42, S43, K149, N248, S279, V320, T325, Q395 and K418.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/