MULTIPARTICULAR FORMS WITH PROLONGED RELEASE, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING SAME FOR THE TREATMENT AND / OR PREVENTION OF CYCTINURIA
The present invention relates to a novel pharmaceutical form, in the form of a multiparticulate spherical or cylindrical or plane (concave), containing an alkalinizing of urine, such as the citrate salt or bicarbonate or their mixture as the active substance. The spherical multiparticulates (microgranules, minigranules, pellets) are prepared by conventional wet or dry granulation () or by any other method of granulation (extrusion and spheronization), and the cylindrical multiparticulates of concave shapes or flat by compression, with a release profile provided by the matrix or by a layer of coating. The present invention also extends to the processes of preparation and to the use of such multiparticulates spherical or cylindrical for the treatment and / or the prevention of cystinuria or other nephrolithiasis. Applications: pharmacy and veterinary
