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Storage-stable, functionally intact fibrinogen
专利权人:
Johann Eibl
发明人:
Johann Eibl
申请号:
US13000934
公开号:
US08741846B2
申请日:
2009.06.22
申请国别(地区):
US
年份:
2014
代理人:
摘要:
Method for the production of a fibrinogen solution from an aqueous solution that contains functionally intact fibrinogen and is contaminated with profibrin and/or fibrin monomers and/or fibrin monomer complexes and/or fibrin split products, characterized in that the contaminations are precipitated using a non-denaturing precipitating agent at a temperature ranging from −4° to +4° and calcium ion activity not exceeding that of a 1,000 μM CaCl2 solution and are separated from the solution by means of filtering or centrifugation process.
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