ЛИ Патрис А. (US),ВИНСКИ Шаннон Л. (US),КОЧ Кевин (US)
申请号：
RU2014142700
公开号：
RU2014142700A
申请日:
2013.03.25
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. Compound N4- (4 - ([1,2,4] triazolo [1,5-a] pyridin-7-yloxy) -3-methylphenyl) -N6- (4,4-dimethyl-4,5-digadrooxazole -2-yl) quinazolin-4,6-diamine for use in the treatment of local or metastatic brain cancer that is caused by overexpression or amplification of ErbB2, characterized in that said N4- (4 - ([1,2,4] triazolo [1,5-a] pyridin-7-yloxy) -3-methylphenyl) -N6- (4,4-dimethyl-4,5-dihydrooxazol-2-yl) quinazolin-4,6-diamine is administered as a tablet in 600 mg twice daily in combination with trastuzumab, capecitabine, bevacizumab, paclitaxel or docetaxel. 2. Compound (2 - ((4 - ((4 - ([1,2,4] triazolo [1,5-a] pyridin-7-yloxy) -3-methylphenyl) amino) quinazolin-6-yl) amino) - 4-methyl-4,5-dihydrooxazol-4-yl) methanol for use in the treatment of local or metastatic brain cancer, which is caused by excessive expression or amplification of ErbB2, characterized in that (2 - ((4 - ((4- ([1,2,4] triazolo [1,5-a] pyridin-7-yloxy) -3-methylphenyl) amino) quinazolin-6-yl) amino) -4-methyl-4,5-dihydrooxazol-4- il) methanol is administered in the form of tablets at a dose of 0.1 to 2000 mg per day in combination with trastuzumab, capecitabine, bevacizumab, paclitaxel and whether docetaxel. 3. N4- (4 - ([1,2,4] triazolo [1,5-a] pyridin-7-yloxy) -3-methylphenyl) -N6- (4,4-dimethyl-4,5-dihydrooxazole-2- il) quinazolin-4,6-diamine or (2 - ((4 - ((4 - ([1,2,4] triazolo [1,5-a] pyridin-7-yloxy) -3-methylphenyl) amino) quinazolin-6-yl) amino) -4-methyl-4,5-dihydrooxazol-4-yl) methanol for use in the treatment of local or metastatic brain cancer, which is caused by excessive expression or amplification of ErbB2.4. N4- (4 - ([1,2,4] triazolo [1,5-a] pyridin-7-yloxy) -3-methylphenyl) -N6- (4,4-dimethyl-4,5-dihydrooxazole-2- il) quinazolin-4,6-diamine or (2 - ((4 - ((4 - ([1,2,4] triazolo [1,5-a] pyridin-7-yloxy) -3-methylphenyl) amino) quinazolin-6-yl) amino) -4-methyl-4,5-dihydrooxazol-4-yl) methanol for use in the treatment of local or metastatic brain cancer, which1. Соединение N
