CAPPED CYCLODEXTRIN-HYDROPHOBIC MOIETY CONJUGATE, CYCLODEXTRIN SUPRAMOLECULAR POLYMER, AND CYCLODEXTRIN-siRNA COMPLEX AND METHOD OF SYNTHESIS THEREOF农业专利-农业专业知识服务系统

专利权人:: Universite Paris Descartes;Institut National De La Sante Et De La Recherche Medicale (INSERM);Centre National De La Recherche Scientifique;Sorbonne Universite;Assistance Publique - Hopitaux De Paris

发明人:: Matthieu SOLLOGOUB,Vincent CALVEZ,Anne-Geneviève MARCELIN,Laurent BOUTEILLER,Mickaël MENAND,Pierre EVENOU,Adélie GOTHLAND,Dmitri COLESNIC,Julien ROSSIGNOL

摘要：: The invention relates to a capped cyclodextrin-hydrophobic moiety conjugate, to a supramolecular polymer formed of capped cyclodextrin-hydrophobic moiety conjugates according to the invention and to a siRNA-cyclodextrin complex comprising a supramolecular polymer according to the invention. The invention also relates to a method for manufacturing the capped cyclodextrin-hydrophobic moiety conjugate, the supramolecular polymer, the siRNA-cyclodextrin complex according to the invention. The capped cyclodextrin-hydrophobic moiety conjugate of the invention comprises a capped cyclodextrin group and at least one hydrophobic moiety bound by a first linker to one of the carbon atoms of the cap. The invention can be used for various applications in particular in the pharmaceutical field.