The present application relates to an immunogenic composition comprising a fragment of staphylococcal Isd proteins such as IsdH IsdA containing the NEAT domain, IsdB, or IsdC. Staphylococcal extracellular component binding protein and NEAT domain of staphylococcal Isd proteins involved in iron / heme uptake system, for example, as well as fusion proteins, including the NEAT domains of Isd proteins derived from and the second NEAT domain of staphylococcal Isd protein first , I also discloses fusion proteins comprising the ligand binding domain of SdrE ClfA, ClfB, SdrC, or SdrD. None [Selection Figure]本出願は、NEATドメインを含むIsdA、IsdB、IsdCまたはIsdHなどのブドウ球菌Isdタンパク質の断片を含む免疫原性組成物に関する。第1のブドウ球菌Isdタンパク質のNEATドメインおよび第2のIsdタンパク質由来のNEATドメインを含む融合タンパク質、ならびに鉄/ヘム取り込みシステムに関わるブドウ球菌Isdタンパク質のNEATドメインおよびブドウ球菌細胞外成分結合タンパク質、例えば、ClfA、ClfB、SdrC、SdrDまたはSdrEのリガンド結合ドメインを含む融合タンパク質も開示する。【選択図】なし
