PROBLEM TO BE SOLVED: To provide an external-application ultrasonic contrast medium consisting of microbubbles.SOLUTION: There is provided an external-application ultrasonic contrast medium consisting of microbubbles which is applied to a local area 301 of a living body surface by: dispersing a microbubble material selected from albumin, a polymer, a liposome, a copolymer, and a mixture, and a combination of them, in a medium selected from an isotonic physiological salt solution, an agar gel, an aloe gel, a local gel, and a combination of them and applying it to the living body surface to form a coating including the multiple microbubbles. There is provided an external-application ultrasonic contrast medium consisting of microbubbles according to the forementioned contrast medium, which has a microbubble concentration of 1×109-2×109 particles/mL, and particle sizes in a range of 0.5-2.5 μm.COPYRIGHT: (C)2015,JPO&INPIT【課題】外用微小気泡超音波造影剤の提供。【解決手段】アルブミン、ポリマー、リポソーム、コポリマー、またはこれらの混合物、またはこれらの組合せから選択される微小気泡材料を、等張生理食塩水、寒天ゲル、アロエ・ゲル、局所ゲル、またはこれらの組合せから選択される媒体に分散し、複数の微小気泡を含むコーティングにより生体の体表の局所領域301に適用する、外用タイプの微小気泡超音波造影剤。該微小気泡の濃度が1×109~2×109粒子/mlであり、粒度が0.5~2.5μmである微小気泡超音波造影剤。【選択図】図1
