Hyper IgE Animal Model with Enhanced Immunoglobulin Heavy Chain Class Switching to C-epsilon

• 收藏
• 分享

专利权人:

Shahram Misaghi

发明人:

Shahram Misaghi,Ali Zarrin

申请号：

US13255226

公开号：

US20120202985A1

申请日:

2010.02.26

申请国别(地区):

US

年份:

2012

代理人:

摘要：

Described herein are recombinant non-human cells and animals having an alteration of the Sε region such that there is an elevated IgE level. Also described herein is an alteration in the IgH locus allows for enhanced class switch recombination (CSR) such that the desired heavy chain isotype is expressed at an elevated level relative to an unmodified cell.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/