DOODS HENRI,KUELZER RAIMUND,PELCMAN BENJAMIN,ROENN ROBERT,PRIEPKE HENNING,STENKAMP DIRK,PFAU ROLAND
申请号：
NZ70673011
公开号：
NZ706730A
申请日:
2011.08.19
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Provided are benzimidazole-carboxamide derivative compounds of the general formula I, wherein the variables are as defined in the specification. Examples of the compounds include N-(trans-4-Trifluoromethyl-cyclohex-1-yl)-2-{ 2, 6-dichloro-3-[(2,2-dimethyl-propionylamino)methyl]-phenylamino } -6-(2 ,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide and N-(3-Chloro-4-fluoro-phenyl)-2-{ 2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]phenylamino} -6-(2-fluoroethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide. The compounds are inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1). The compounds may be useful in the treatment of inflammatory diseases, such as rheumatoid arthritis, osteoarthritis, inflammatory bowel syndrome, lupus erythematodes, asthma and COPD and conditions associated with inflammatory diseases, such as pain.
