Timothy John Mitchell,Lea-Ann Kirkham,Graeme James Cowan,Gillian Douce
申请号：
US12304878
公开号：
US09370557B2
申请日:
2007.06.15
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention relates to the use of bacterial cytolysin proteins, such as pneumolysin, as adjuvants for stimulating or enhancing immune responses against co-administered target antigens. Desirably, the target antigen is provided as a fusion protein with the cytolysin. The inventors have found that cytolysins may be particularly effective for stimulation of mucosal immune responses against the target antigen.
