Devices for the preparation of depleted blood products that provide for the depletion of oxygen, carbon dioxide, or oxygen and carbon dioxide are described. A depletion device (100) comprises an enclosure (103), one or more liquid chambers (101) and one or more depletion chambers (102). A gas permeable barrier (107) separates the liquid chamber(s) from the depletion chamber(s). The depletion chamber contains depletion media (106) such as a solid O2 and CO2 sorbent combination. The depletion chamber may also comprise a gas inlet and a gas outlet through which a depletion gas such as argon may enter and exit the device. The liquid chamber may comprise flow control features (108) that direct the flow of liquid against the gas permeable barrier(s). In addition, devices for the replenishment of oxygen and other gases to an anaerobic blood product are described.
