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NOVEL IMIDAZOPYRIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING CANCER
专利权人:
DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION
发明人:
Hwan Geun Choi,Jung Beom Son,Shinae Kim,Seungyeon Lee,Eunhwa Ko,Joongheui Cho,Seock Yong Kang,So Young Kim,Jin-Hee Park,Yi Kyung Ko,Hee Yoon Ryu,Nam Doo Kim,Hyunkyoung Kim,Younho Lee,Sun-Hwa Lee,Dayea
申请号:
US16311654
公开号:
US20190315738A1
申请日:
2017.06.20
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The present invention relates to a novel imidazopyridine derivative, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating cancer. The novel imidazopyridine derivative according to the present invention, a stereoisomer thereof and a pharmaceutically acceptable salt thereof can effectively inhibit cancer-related kinases, are excellent in inhibiting proliferation of cancer cells in a cancer cell line, and effectively inhibit proliferation of cancer cells (cancer cell apoptosis) in a cancer cell heterograft model, and thus can be useful as a pharmaceutical composition containing the same as an active ingredient for preventing or treating cancer.Also, the novel imidazopyridine derivative according to the present invention, the stereoisomer thereof, and the pharmaceutically acceptable salt thereof can effectively inhibit Src and Fyn, thereby being useful as a pharmaceutical composition for preventing or treating the Src and Fyn related diseases, and in particular, have been confirmed to be useful in diabetic nephropathy in animal model experiments. Therefore, the compound of the present invention can be effective as a pharmaceutical composition containing the same as an active ingredient for preventing or treating diabetic nephropathy.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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