Self replicating RNA Molecule comprising a First Protein or fragment thereof of a herpes virus and a Nucleotide sequence that encodes a Second Protein or fragment thereof of the herpes virus； Alphavirus replicon Particle composition (PVR)； com On the use of autoreplicante VRP； RNA that serves to form a Protein Complex in an ECLula.
LILJA, ANDERS,LOOMIS, REBECCA,FRANTI, MICHAEL,MASON, PETER
申请号：
CL2013000984
公开号：
CL2013000984A1
申请日:
2013.04.11
申请国别(地区):
CL
年份:
2013
代理人:
摘要：
This disclosure provides platforms for delivery of herpes virus proteins to cells, particularly proteins that form complexesIn some embodiments these proteins and the complexes they form elicit potent neutralizing antibodies. Thus, presentation of herpes virus proteins using the disclosed platforms permits the generation of broad and potent immune responses useful for vaccine development.MOLECULA DE ARN AUTO-REPLICANTE QUE COMPRENDE UNA PRIMERA PROTEINA O FRAGMENTO DE LA MISMA DE UN VIRUS DEL HERPES Y UNA SEGUNDA SECUENCIA DE NUCLEOTIDOS QUE CODIFICA UNA SEGUNDA PROTEINA O FRAGMENTO DE LA MISMA DE DICHO VIRUS DEL HERPES； PARTICULA DE REPLICON DE ALFAVIRUS (VRP)； COMPOSICION QUE COMPRENDE EL VRP； USO DEL ARN AUTOREPLICANTE PORQUE SIRVE PARA FORMAR UN COMPLEJO DE PROTEINAS EN UNA CELULA.
