您的位置: 首页 > 农业专利 > 详情页

Method for use of microdialysis
专利权人:
Robert A. Bellantone
发明人:
Robert A. Bellantone
申请号:
US13573244
公开号:
US08647295B2
申请日:
2012.09.04
申请国别(地区):
US
年份:
2014
代理人:
摘要:
Very accurate measurements of mass transfer can be made rapidly by permitting diffusion of an agent desired to be measured into or out of a small, very precisely known volume of a microdialysis probe, then rapidly pumping or flushing (“pulsing”) the probe with a known volume of fluid as a single pulse. The diffusion and pulsing may be repeated. The method, hereinafter called pulsatile microdialysis (PMD) to distinguish it from prior art continuous flow microdialysis, is useful for measurements in a number of processes, including protein binding, adsorption to binding agents such as activated charcoal, release from microemulsion drug delivery systems, determination of drug diffusion coefficients and concentrations, and for various other purposes.The method is based on mathematical manipulation of Ficks Laws. Resulting equations were verified against experimental data using methazolamide, warfarin and benzocaine as test drugs.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充