COMPOSITION ET PROCÉDÉ DE CIBLAGE DE CELLULES TUEUSES NATURELLES EN IMMUNOTHÉRAPIE POUR SURMONTER LA SUPPRESSION TUMORALE AVEC DES NANOPARTICULES DE DIOXYDE DE MANGANÈSE
The present invention provides manganese dioxide nanoparticles complexed with one or more nucleic acid sequences for introduction into NK cells for an immunotherapy treatment. The nanoparticles discussed herein target and silence TGF-β in order to reactivate NK cells that have been inactivated or suppressed. Provided is a method of inducing an anti-cancer immune response in a subject, comprising administering to immune cells of the subject a pharmaceutically effective amount of a nanoparticle composition comprising a manganese dioxide nanoparticle complexed with a nucleic acid sequence in an amount sufficient to induce, enhance, or promote an immune response against the cancer in the subject. The invention also comprises a manganese dioxide nanoparticle formulation, comprising the manganese dioxide nanoparticle(s) as described and a pharmaceutically acceptable carrier. The invention also relates to a method of scavenging reactive oxygen species in a tissue, comprising contacting the tissue with the manganese dioxide nanoparticle(s) as described herein.La présente invention concerne des nanoparticules de dioxyde de manganèse complexées avec une séquence d'acide nucléique pour l'introduction dans des cellules NK pour un traitement d'immunothérapie.
