In one embodiment, an ambulatory insulin infusion system may include an administration module for insulin administration, a data collection module for collecting data relevant for the bolus amount, and a delay module. The administration module may administer insulin continuously according to a basal profile and a bolus on demand. The bolus has a bolus amount. The data collection module may be operatively coupled to the administration module. The delay module may trigger administration of the bolus a therapeutically significant delay interval after the data is collected.