The Board of Trustees of the Leland Stanford Junior University
发明人:
Isabella A. Graef,Mamoun M. Alhamadsheh
申请号：
US15092446
公开号：
US20160374961A1
申请日:
2016.04.06
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Disclosed herein are compounds and compositions thereof which find use in increasing stability of TTR tetramers reducing its tendency to misfold and form aggregates. Also provided herein are methods for using these compounds and compositions for increasing stability of TTR and therby decreasing aggegate formation by TTR. Also disclosed herein are methods to screen for candidate compounds that increase stability of TTR. Also disclosed herein are heterobifunctional compounds that include a TTR binding compound connected to a targeting moiety via a linker, for use in disrupting PP is of a target protein.
