ANDERSON DANIEL G,GU ZHEN,AIMETTI ALEX ARTHUR,LANGER ROBERT S
申请号：
IN10368/DELNP/2015
公开号：
IN2015DN10368A
申请日:
2015.11.09
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
A system for "smart" delivery of a therapeutic prophylactic or diagnostic agent such as glucose mediated delivery of insulin through an injectable nano network consisting of oppositely charged dextran nanoparticles encapsulating insulin and glucose specific enzymes forming a gel like 3D scaffold. As demonstrated by the examples the system effectively dissociates to release insulin in a hyperglycemic condition where the catalytic conversion of glucose into gluconic acid and the subsequent degradation of polymeric matrix are facilitated. This formulation design provides a delivery strategy for both self regulated and long term diabetes management.
